Bumble bees occupy a different category than honey bees, wasps, or hornets. They're critical pollinators (especially for tomatoes, blueberries, cranberries, peppers, and eggplant, all of which depend on buzz pollination that bumble bees can do and honey bees can't), they live in small annual colonies of 50 to 400 workers that die at first frost, they're non-aggressive defenders that almost never sting unprovoked, and many North American species are in documented decline. The rusty patched bumble bee became the first federally endangered bee species in 2017. Several others are likely candidates in coming years.
All of that adds up to a different default response. For honey bees in a wall void or yellow jackets near a doorway, the question is when to treat. For bumble bees, the question is whether to intervene at all. The honest answer for a colony in a remote garden corner, unused yard area, or back fence line is leave it alone. The colony will be gone in October. The site rarely gets reused next year. The bees did real pollination work for your garden and your neighbors' gardens all summer. Nothing about the situation actually requires treatment.
Where intervention legitimately matters is when the nest location creates unavoidable conflict, walking paths, doorways used daily, active play areas, garden beds worked weekly, wall voids near indoor living space, allergic family members in regular-use areas. In those cases the right response is relocation, not killing. Many wildlife rehabbers, native bee conservation groups, and beekeepers in most regions will move a bumble bee colony for $150 to $400 rather than see it destroyed. A specialist who knows bumble bees will route you to the right local contact instead of jumping to pesticide.
When relocation truly isn't possible, removal is done at dusk in protective gear when the entire colony is inside the nest. Comb, dead bees, and brood are removed afterward, especially important in wall void cases where leftover material would attract ants, wax moths, and mice over the following months. A specialist also helps confirm the species, the federally endangered rusty patched bumble bee is protected and a pest company that doesn't know the difference is exposing you to legal risk as well as wasting a beneficial colony.